@datarama Two I've played recently is Tangle Tower and The Mermaid Mask.
Apart from just being good point-and-click mysteries, they sport some of the best character animation work I've ever seen in... I was going to say a point-and-click game, but I think maybe in any game, really?
I think I have to reach for Later Alligator to find anything really comparable.

@booksquirrel Gecko Gods is unbeatable for character animation. :P